Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells
نویسندگان
چکیده
منابع مشابه
Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells
Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility. AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest. To examine the anticancer bioactivity of PEG-AuNPs, we investigated their effect on human chronic myeloid leukemia K562 cells. The resu...
متن کاملArsenic targets tubulins to induce apoptosis in myeloid leukemia cells.
Arsenic exhibits a differential toxicity to cancer cells. At a high concentration (>5 microM), As2O3 causes acute necrosis in various cell lines. At a lower concentration (0.5-5 microm), it induces myeloid cell maturation and an arrest in metaphase, leading to apoptosis. As2O3-treated cells have features found with both tubulin-assembling enhancers (Taxol) and inhibitors (colchicine). Prior tre...
متن کاملAll-trans retinoic acid might also induce apoptosis in freshly isolated chronic myeloid leukemia cells.
strong correlation was found between the two variables (r = 0.86; p<0.0001), as suggested by linear regression analysis. The best results were obtained when the number of CD34 cells in PB was greater than 50 μL, while the worst results were related to a level of less than 10 μL (Figure 1). Only in 5 cases, because of the particular clinical history of the patients, did we perform leukapheresis ...
متن کاملGold nanoparticles induce apoptosis in MCF-7 human breast cancer cells.
BACKGROUND Gold nanoparticles have recently been investigated with respect to biocompatibility according to their interactions with cells. The purpose of this study was to examine cytotoxicity and apoptosis induction by well-characterized gold nanoparticles in human breast epithelial MCF-7 cells. METHODS Apoptosis was assessed by TUNEL, cytotoxicity by MTT assay and caspase 3, 9, p53, Bax and...
متن کاملAkt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
BACKGROUND The phosphatidylinositol-3-kinase/Akt pathway has been described to be critical in the survival of chronic lymphocytic leukemia cells. In this study we analyzed the effect of two selective chemical inhibitors of Akt (Akti-1/2 and A-443654) on the survival of chronic lymphocytic leukemia cells. DESIGN AND METHODS Using cytometry we studied the cytotoxic effects of Akt inhibitors on ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMed Research International
سال: 2014
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2014/182353